 | CatalogNo.: K-5000A Description: EchelonBioscience’sHumanAnti-PEthAutologousIgGELISAisadirectassayinwhichthesignalisproportionaltotheamountofautologousanti-PEthIgGcontainedinthesample.Theserum(orplasma)sampleisaddedtoaPEth-coatedplateforbinding.Aperoxidase-linkedsecondarydetectorandcolorimetricsubstrateareusedtodetecttheamountofanti-PEthantibodyboundtotheplate.Thecolorimetricsignalisreadatabsorbance450nmandisdirectlyproportionaltotheamountofautologousanti-PEthIgGinthesample. | ||
Ethanol(EtOH)hasmultipleeffectsonhumansandotheranimals.Alcoholaddictionandorgandamageareactiveareasofresearchwithaneedforresearchreagentsandtools.1Phosphatidylethanol(PEth)isadirectmetaboliteofEtOHandhasbeendescribedasalong-livedbioMarkerforalcoholingestion.2,3ItispossIBLethatPEthisinvolvedintheneurological4,protective5,andharmful6effectsofalcohol,butthemechanismsarestillbeingexplored. Storage4°CReferences1.Freeman,W.M.;Vrana,K.E.FutureProspectsforbiomarkersofalcoholconsumptionandalcohol-induceddisorders.AlcoholClinExpRes2010,34,946-54.2.Viel,G.;etal.Phosphatidylethanolinbloodasamarkerofchronicalcoholuse:asystematicreviewandmeta-analysis.IntJMolSci2012,13,14788-812. 3.Wurst,F.M.;etal.Phosphatidylethanol:normalizationduringdetoxification,genderaspectsandcorrelationwithotherbiomarkersandself-reports.AddictBiol2010,15,88-95. 4.Esteban-Pretel,G.;etal.PolyphosphoinositidemetabolismandGolgicomplexmorphologyinhippocampalneuronsinprimarycultureisalteredbychronicethanolexposure.AlcoholAlcohol2012,48,15-27. 5.Foster,D.A.;etal.Reducedmortalityandmoderatealcoholconsumption:thephospholipaseD-mTORconnection.CellCycle2010,9,1291-4. 6.Pannequin,J.;atal.PhosphatidylethanolaccumulationpromotesintestinalhyperplasiabyinducingZONAB-mediatedcelldensityincreaseinresponsetochronicethanolexposure.MolCancerRes2007,5,1147-57. 7.Nissinen,A.E.;etal.Lowplasmaantibodiesspecificforphosphatidylethanolinalcoholabusersandpatientswithalcoholicpancreatitis.AddictBiol,2011.17(6):p.1057-67. RelatedProducts PhosphatidylethanolELISA(K-5000) Anti-PhosphatidylethanolAntibody(Z-PETH) Phosphatidylethanolcoatedbeads(P-BPEth) SyntheticPhosphatidylethanols | |||
