
![]() ![]() | CatalogNo.: K-1700s Description: TheCollagenIVELISAKitIIisasandwichELISAforthequantificationofsolublehumanCollagenIV. AssayRange:3.1-200ng/mLCollagenIV SampleVolume:20μL/sampleforresultsinduplicate | ||
Productbackground:CollagenIVisamajorcomponentoftheextracellularmatrixandprovidesthemainstructuralsupportforthebasementmembrane.IthasbeendemonstratedthatavarietyofdiseasescausealterationsinCollagenIVsynthesis,degradationandreleaseatthetissuelevel.TheserumlevelofCollagenIVisalteredinseveraltypesofdiseases,includingliverfibrosis(agoodindexwithhyaluronicacid)andcirhosis.ResearchhasshownthatthelossofCollagenIVinthebasementmembrane(withaconcurrentincreaseinCollagenaseactivity)positivelycorrelateswiththeprogressionofcancer.CollagenIVintheseramaybeindicativeoftissueCollagenIVdegradationandmaycorrelatewithcancerprogression. |