Purified Anti-PtdIns(3,4,5)P3 monoclonal antibody conjugated with biotin.Subclass: IgMSource: MouseApplications: ELISA, Immunofluorescence

Product Background:Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Storage

2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times.

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Featured in Publications

1) Anzelon, A. N., H. Wu, et al. (2003). “Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.” Nat Immunol 4(3): 287-94.2) Verkoczy, L., B. Duong, et al. (2007). “Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.” J Immunol 178(10): 6332-41.3) Rotman, T., N. Etkovitz, et al. (2010). “PKA and PKC{alpha}/PP1{gamma}2 play opposing roles in the regulation of PI3K activation in bovine sperm.” Reproduction: REP-09-0314.

Product keywords: PIP3, PI(3,4,5)P3, PtdIns(3,4,5)P3, IgM, anti-PIP3