Purified Anti-PtdIns(4,5)P2 (2C11) monoclonal antibody.Subclass: IgMSource: MouseApplications: ELISA, Immunofluorescence, Protein-Lipid Overlay (PIP Strip)Clonality: Monoclonal , 2C11

Product Background: Phosphoinositides (PIP_ns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PIP3.

Storage

2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times

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Featured in Publications

1) Terebiznik, M. R., O. V. Vieira, et al. (2002). “Elimination of host cell PtdIns(4,5)P(2) by bacterial SigD promotes membrane fission during invasion by Salmonella.” Nat Cell Biol 4(10): 766-73.2) Hirono, M., C. S. Denis, et al. (2004). “Hair cells require phosphatidylinositol 4,5-bisphosphate for mechanical transduction and adaptation.” Neuron 44(2): 309-20.3) Leloup, L., H. Shao, et al. (2010). “m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate.” Journal of Biological Chemistry 285(43): 33549-33566.

Product keywords: PIP2, PI(4,5)P2, PtdIns(4,5)P2, IgM, anti-PIP2