梯队公司/PI3-Kα抑制剂2/1mg/B-0304-1mg
商品编号：
B-0304
市场价：
¥4680.00
美元价：
2340.00
产品分类：
脂质代谢研究
公司分类：
Lipid_metabolism_study
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol is a selective inhibitor for the α-isoform of PI 3-Kinase (IC50: PI 3-Kα = 2 nM, PI 3-Kβ = 16 nM, PI3-Kγ = 660 nM, PI3KC2β = 220 nM)). It showed >1000-fold selectivity vs. protein kinases such as PKA, KDR, PKCa, and E/CDK2 (IC50 = 91, 3.4, 466, 288 μM). It inhibited proliferation of A375 melanoma cells at 580 nM. Also known as PI3-K Inhibitor 2, PIK2.
References
Powered by Bioz See more details on Bioz1) M. Hayakawa, et al. “Synthesis and biological evaluation of 4-morpholino-2-phenyl quinazolines and related derivatives as novel PI3 kinase p110a inhibitors” Bioorg. Med. Chem. 2006, 14, 6847-6858.
| Categories | Biochemical Reagents |
|---|---|
| Filter | Inhibitor, PI3K |
| CAS Number | 371943-05-4 |
| Molecular Formula | C16H15N3O2S |
| Molecular Weight (g/mol) | 313.4 |
| Purity | >95% |
| Storage | 4 °C or below |
品牌介绍
Echelon产品线★合成磷脂、磷酸肌醇、鞘脂及其衍生物★脂蛋白质相互作用工具★脂质含量检测试剂盒★脂质相关生物酶活性检测，抑制剂筛选试剂盒
