GroPI(3,4,5)P3 (Glycerophosphoinositol 3,4,5-triphosphate) is a synthetic phosphoinositide without acyl chains on the 1- & 2-positions of the glycerol.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2. Glycerophosphoinositol 3,4,5-triphosphate (GroPIP3) is missing the acyl chains from the 1- & 2-positions of the glycerol.
| Categories | Lipids |
|---|---|
| Filter | Glycerolphosphoinositide, Phosphoinositides |
| CAS Number | 350685-86-8 |
| Molecular Formula | C9H15Na7O20P4 |
| Molecular Weight (g/mol) | 728.00 |
| Purity | >95% |
| Storage | -20 °C or below |
