Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.
GloPIPs are labeled at the sn-1 position with BODIPY®-FL (505/513), BODIPY®-TMR (544/574), or biotin. The sn-1 linkage in these labeled PIPs has been changed to a more stable amide from an ester. Results from experiments conducted at Echelon indicated that this minor chemical change did not have a significant effect in any of the applications tested.
Bulk discounts available, please email echelon@echelon-inc.com for information.
| Categories | Lipids |
|---|---|
| Filter | Biotinylated, Phosphoinositides, PI(3,4)P2 |
| Molecular Formula | C31H52N4Na5O20P3S |
| Molecular Weight (g/mol) | 1,040.7 |
| Purity | >95% |
| Storage | -20 °C or below |
