BODIPY TMR PI(4,5)P2 (BODIPY TMR Phosphatidylinositol 4,5-bisphosphate) is a water soluble analog of PI(4,5)P2 (PIP2) labeled with the orange fluorophore, Bodipy®-TMR, at the sn-1 position.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3.
Excitation/Emission
542/574 nm
Storage
-20 °C, protect from light
Publications
Powered by Bioz See more details on Bioz1) Cabanos C, Wang M, Han X, Hansen SB (2017) A Soluble Fluorescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels. Cell Rep 20(6):1287–1294
Bulk discounts available, please email echelon@echelon-inc.com for information.
| Categories | Lipids |
|---|---|
| Filter | Fluorescent, Phosphoinositides, PI(4,5)P2 |
| Excitation/Emission | 542/574 nm |
| Molecular Formula | C78H147BF2N9O22P3 |
| Molecular Weight (g/mol) | 1,704.78 |
| Purity | >95% |
| Storage | -20 °C or below, protect from light |
