Biotin Phosphatidylinositol 4,5-bisphosphate is a water soluble analog of PI(4,5)P2 (PIP2) labeled with biotin at the sn-1 position.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4,5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions, PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues. It is also a substrate for class I phosphoinositide 3-kinase (PI3-K) forming PI(3,4,5)P3.

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1) Rzepecki, P. W. and G. D. Prestwich (2002). “Synthesis of hybrid lipid probes: derivatives of phosphatidylethanolamine-extended phosphatidylinositol 4,5-bisphosphate (Pea-PIP(2)).” J Org Chem 67(16): 5454-60.2) Goksoy, E., Y.-Q. Ma, et al. (2008). “Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation.” Molecular cell 31(1): 124.3) Michailidis, I., R. Rusinova, et al. (2011). “Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation.” Pflugers Archiv European Journal of Physiology 461(3): 387.4) A. L. Egea-Jimenez, R. Gallardo, A. Garcia-Pino, Y. Ivarsson, A. M. Wawrzyniak, R. Kashyap, R. Loris, J. Schymkowitz, F. Rousseau and P. Zimmermann. (2016) “Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling” Nat Commun 7, DOI: 10.1038/ncomms12101

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