BODIPY TMR Phosphatidylinositol 3,4-bisphosphate is a water soluble analog of PI(3,4)P2 labeled with the orange fluorophore, Bodipy®-TMR, at the sn-1 position.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.
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| Categories | Lipids |
|---|---|
| Filter | Fluorescent, Phosphoinositides, PI(3,4)P2 |
| Excitation/Emission | 542/574 nm |
| Molecular Formula | C78H147BF2N9O22P3 |
| Molecular Weight (g/mol) | 1,704.78 |
| Purity | >95% |
| Storage | -20 °C or below, protect from light |
