Phosphatidylinositol 4-phosphate diC4 (PI(4)P diC4) is a synthetic, purified dibutanoyl PI(4)P.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4-phosphate (PI(4)P) is the biosynthetic precursor to PI(4,5)P2 and has an important roles in regulating sphingomyelin and glycosphingolipid metabolism and membrane trafficking at the exit of the Golgi complex.

Product Keywords: D-myo-Phosphatidylinositol 4-phosphate, Dibutanoyl Phosphatidylinositol 4-phosphate, PtdIns(4)P C4, PI(4)P C4, or PI4P

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1) Guo, J., M. R. Wenk, et al. (2003). “Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles.” Proc Natl Acad Sci U S A 100(7): 3995-4000.2) Schoebel, S., W. Blankenfeldt, et al. (2010). “High-affinity binding of phosphatidylinositol 4-phosphate by Legionella pneumophila DrrA.” EMBO Rep 11(8): 598.3) Ramel, D., F. Lagarrigue, et al. (2011). “Shigella flexneri Infection Generates the Lipid PI5P to Alter Endocytosis and Prevent Termination of EGFR Signaling.” Sci. Signal. 4(191): ra61