PI(3,4,5)P3 (Phosphatidylinositol 3,4,5-trisphosphate) 18:0/20:4 is a synthetic, purified PI(3,4,5)P3 with stearoyl and arachidonoyl acyl groups.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.
Product Keywords: 1-Stearoyl-2-arachidonoyl-phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3 (18:0/20:4), PI(3,4,5)P3 (18:0/20:4), or PIP3
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Powered by Bioz See more details on Bioz| Categories | Lipids |
|---|---|
| Filter | Phosphoinositides, PI(3,4,5)P3 |
| CAS Number | 799268-60-3 |
| Molecular Formula | C47H82Na4O22P4 |
| Molecular Weight (g/mol) | 1,214.99 |
| Purity | >95% |
| Storage | -20 °C or below |
