PI(3,5)P2 diC4 (Phosphatidylinositol 3,5-bisphosphate diC4) is a synthetic, purified dibutanoyl PI(3,5)P2.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).

Product Keywords: Dibutanoyl Phosphatidylinositol 3,5-bisphosphate, PtdIns(3,5)P2 C4, PI(3,5)P2

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Publications

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1. He, F., M. Mao, et al. (2004). “Enhancement of phototransduction g protein-effector interactions by phosphoinositides.” J Biol Chem 279(10): 8986-90.2. Fernandes, F., K. Chen, et al. (2011). “Phosphoinositides direct equine infectious anemia virus gag trafficking and release.” Traffic 12(4): 438-51.3. Pylypenko, O., R. Lundmark, et al. (2007). “The PX-BAR membrane-remodeling unit of sorting nexin 9.” EMBO J 26(22): 4788.4. Fernandes, F., et al. (2011). “Phosphoinositides direct equine infectious anemia virus gag trafficking and release.” Traffic 12(4): 438-451.5. Prchal, J., et al. (2012). “The Structure of Myristoylated Mason-Pfizer Monkey Virus Matrix Protein and the Role of Phosphatidylinositol-(4,5)-Bisphosphate in Its Membrane Binding.” Journal of Molecular Biology 423(3): 427-438.