PI(3)P diC4 (Phosphatidylinositol 3-phosphate diC4) is a synthetic, purified dibutanoyl PI(3)P.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4.

Product Keywords: Dibutanoyl Phosphatidylinositol 3-phosphate, PtdIns(3)P C4, PI(3)P C4, or PI3P C4

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1) Sankaran, V. G., D. E. Klein, et al. (2001). “High-affinity binding of a fyve domain to phosphatidylinositol 3- phosphate requires intact phospholipid but not fyve domain oligomerization.” Biochemistry 40(29): 8581-7.2) Bravo, J., D. Karathanassis, et al. (2001). “The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.” Mol Cell 8(4): 829-39.3) Fernandes, F., K. Chen, et al. (2011). “Phosphoinositides direct equine infectious anemia virus gag trafficking and release.” Traffic 12(4): 438-51.