Phosphatidylinositol diC4 (PI diC4) is a synthetic, purified dibutanoyl PI.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol (PI or PtdIns) is biosynthesized from CDP-diacylglycerol and inositol by phosphatidylinositol synthase. PI is the building block for phosphoinositide polyphosphates through phosphorylation by PI-kinases and is a substrate for PI-PLC yielding diacylgelycerol.

Alternate Names: Dibutanoyl Phosphatidylinositol, PtdIns C4, PI C4, (4:0/4:0) PI

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Publications

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1) Guo, J., M. R. Wenk, et al. (2003). “Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles.” Proc Natl Acad Sci U S A 100(7): 3995-4000.2) He, F., M. Mao, et al. (2004). “Enhancement of phototransduction g protein-effector interactions by phosphoinositides.” J Biol Chem 279(10): 8986-90.3) Kobayashi, M., R. K. Mutharasan, et al. (2004). “Identification of hydrophobic interactions between proteins and lipids: free fatty acids activate phospholipase C delta1 via allosterism.” Biochemistry 43(23): 7522-33.