Resveratrol is a class IA PI3K inhibitor, activates SIRT1, and displays antiproliferative effect on human breast epithelial cells. By depolarization of mitochondrial membrane and caspase-9 activation resveratrol induces apoptosis. In addition, Resveratrol inhibits ribonucleotide reductase and DNA synthesis, cyclooxygenase-1, PKD, and eicosanoid synthesis.

References

1) S Fröjdö, et al. Resveratrol is a class IA phosphoinositide 3-kinase inhibitor Biochem J. 406 511 (2007)

2) K.T. Howitz et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 191 (2003)

3) O.P. Mgbonyebi et al. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int. J. Oncol. 12 865 (1998)

3) J. Dorrie et al. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res. 61 4731 (2001)

4) M. Fontecave et al. Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Lett. 421 277 (1998)

5) M. Jang, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275 218-220 (1997)

6) J.R. Stewart et al. Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation. Biochem. Pharmacol. 60 1355 (2000)