Recombinant anti-Gelsolin Nanobody, Clone # Nb11, COOH-terminal HA tag.Type: VHH single domainSource: E. ColiApplications: ELISA, Immunoprecipitation, Pull down, western blotClonality: Monoclonal

Background: Gelsolin VHH Antibody was produced in a llama with purified full length human recombinant gelsolin then cloned for recombinant production in E. Coli. Gelsolin is a ubiquitously expressed cytoskeletal protein that breaks the non-covalent bonds between actin monomers in a filament. Fluctuating gelsolin expression has been reported in cancer cells and has been linked to altered motility and invasiveness of certain cancers.

Recombinant anti-Gelsolin Nanobody 11 was developed by Gulliver Biomed.

Storage

Store at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.

Publications

1) Giorgino T, et al. (2019) Nanobody interaction unveils structure, dynamics and proteotoxicity of the Finnish-type amyloidogenic gelsolin variant. Biochim Biophys Acta Mol Basis Dis; 1865(3):648-660.2) Van Overbeke W, et al. (2015) An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model. Hum Mol Genet; 24(9):2492-2507.

Keywords: Gelsolin, nanobody, VHH, antibody, single domain

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