Recombinant anti-c-Src Nanobody, Clone # Nb76, COOH-terminal HA tag.Type: VHH single domainSource: E. ColiApplications: ELISA, Immunoprecipitation, Pull downClonality: Monoclonal

Background: c-Src VHH Antibody was produced in an llama with human recombinant Src fragment comprising amino acids 1-252 then cloned for recombinant production in E. Coli. The kinase Src is a non receptor tyrosine kinase that is activated by immune response receptors, GPCRs, and cytokine receptors. Perturbation of Src contributes to cell transformation, cancer cell invasion and metastasis, and cell cycle progression.

Recombinant anti-c-Src Nanobody 76 was developed by Gulliver Biomed.

Storage

Store at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.

Publications

1) Beghein E. et al. (2018) Cortactin and fascin-1 regulate extracellular vesicle trafficking or invadopodia formatoin and function. Sci Rep; 8(1):156062) Bertier L. et al. (2017) Inhibitory cortactin nanobodies delineate the role of NTA and SH3 domain-specific functions during invadopodium formation and cancer cell invasion. FASEB J; 31(6):2460-2476

Keywords: c-Src, Src kinase, nanobody, VHH, antibody, single domain

‘Nanobody’ and ‘nanobodies’ are registered trademarks of Ablynx N.V.