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当前位置: 首页 > 产品中心 > > Echelon/PI(3,5)P2 Grip/50 ug/G-3501
商品详细Echelon/PI(3,5)P2 Grip/50 ug/G-3501
Echelon/PI(3,5)P2 Grip/50 ug/G-3501
Echelon/PI(3,5)P2 Grip/50 ug/G-3501
商品编号: G-3501
市场价: ¥8820.00
美元价: 4189.50
产地: 美国(厂家直采)
公司:
产品分类: 其他
公司分类:
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

PI(3,5)P2 Grip (G-3501) is a recombinant N-terminal GST fusion PI(3,5)P2 binding protein expressed in E. Coli. G-3501 has been validated for use in ELISA and as a control for lipid pulldown experiments.

Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).

Storage: -20 °C. Aliquot and freeze if intended for multiple uses. Protein will be stable for at least 6 months from date of shipment.


References

1. Dove S.K., Piper, R.C., McEwen, R.K., Yu, J.W., King, M.C., Hughes, D.C., Thuring, J., Holmes, A.B., Cooke, F.T., Michell, R.H., Parker, P.J., & Lemmon,M.A. (2004) Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J. 1-12.

2. Dong X., Shen D., Wang X., Dawson T., Li X., Zhang Q., Cheng X., Zhang Y., Weisman L.S., Delling M. & Xu H. (2010) PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome. Nat Comm 1(38)


Categories

Antibodies & Proteins

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Lipid Binding, PI(3,5)P2

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