CAS Number: 107761-42-2Molecular Weight: 4511.3Salt Form: TFAPurity: >95%Sequence (3-letter): Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OHSequence (1-letter): DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OHStorage: -20 °C or belowSolubility: 1 mg/mL in 50 mM Tris or dissolve 1 mg in 70-80 uL 1% NH4OH then dilute to 1 mg/mL with 1X PBS. Do not store in 1% NH4OH, dilute immediately with PBS.

Beta amyloid (1-42) is the predominant form of β-amyloid protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome. Beta amyloid down-regulates bcl-2 (a key anti-apoptotic protein) and upregulates bax (cell death promoter) with evidence suggesting that it renders neurons vulnerable to age-dependent stress and neurodegeneration

References

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1. Scheuner, D. et al (1996) “Secreted amyloid bold beta−protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease” Nat. Med. 2: 864 – 870.2. Lacor, P. N. et al (2004) “Synaptic Targeting by Alzheimer’s-Related Amyloid β Oligomers” J. Neurosci. 24 (45): 10191-10200.3.Paradis et al (1996) “Amyloid beta peptide of Alzheimer’s disease downregulates bcl-2 and upregulates bax expression in human neurons” J. Neurosci. 16: 7533.