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当前位置: 首页 > 产品中心 > > Echelon/Pan-Akt VHH Antibody/250 ug/Z-N001
商品详细Echelon/Pan-Akt VHH Antibody/250 ug/Z-N001
Echelon/Pan-Akt VHH Antibody/250 ug/Z-N001
Echelon/Pan-Akt VHH Antibody/250 ug/Z-N001
商品编号: Z-N001
市场价: ¥16800.00
美元价: 7980.00
产地: 美国(厂家直采)
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产品分类: 其他
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联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Recombinant anti-Akt Nanobody, Clone # Nb10, COOH-terminal HA tag.Type: VHH single domainSource: E. coliApplications: ELISA, Immunoprecipitation, Pull downClonality: Monoclonal

Background: Pan-Akt VHH Antibody was produced in a llama with a recombinant full length Akt then cloned for recombinant production in E. coli cells. Akt kinases are three highly homologous (Akt 1, 2, 3) isoforms of serine/threonine kinases. Akt, also known as protein kinase b (PKB) is frequently over-activated in cancer and considered as a therapeutic target. However, most small molecule inhibitors lack sufficient specificity and to date there are no effective isoform-specific inhibitors available.

Recombinant anti-Akt Nanobody 10 was developed by Gulliver Biomed.


Storage

Store at -20°C upon arrival. For long term storage, aliquot and store at -80°C. Avoid repeated freeze/thaw cycles.

Publications

1) Merckaert, T. et al. (2020). Development and characterization of protein kinase B/AKT isoform-specific nanobodies. PLoS One. 15:e0240554.2) Merckaert, T. et al. (2021). An AKT2-specific nanobody that targets the hydrophobic motif induces cell cycle arrest, autophagy and loss of focal adhesions in MDA-MB-231 cells.Biomed Pharmacother. 133:111055.

Keywords: Akt, protein kinase b, PKB, nanobody, VHH, antibody


‘Nanobody’ and ‘nanobodies’ are registered trademarks of Ablynx N.V.

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Antibodies & Proteins

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Antibody, Nanobody

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