CAS Number: 143313-51-3Molecular Weight: 492.22Salt Form: N/APurity: >95%Sequence (3-letter): Ac-Tyr-Val-Ala-Asp-CHOSequence (1-letter): Ac-YVAD-CHOStorage: -20 °C or belowSolubility: DMSO (5 mg/ml), water (5 mg/ml), ethanol (30 mg/ml), DMF (30 mg/ml)

N-Ac-Tyr-Val-Ala-Asp-CHO (Ac-YVAD-CHO) is a synthetic peptide that reversibly and selectively inhibits interleukin-1β converting enzyme (ICE; Caspase-1). Caspase-1 is a pro-inflammatory cytokine and like other caspase inhibitors, interferes with the initiation of apoptosis and has numerous possible clinical applications

References

1. Cerretti D.P., et al. (1992) “Molecular cloning of the interleukin-1 beta converting enzyme” Science 256: 97–100.2.Thornberry N.A. et al. (1992) “A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes” Nature 356: 768–774.