CAS Number: 108334-68-5Molecular Weight: 1506.92Salt Form: AcetatePurity: >96%Sequence (3-letter): Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys-OHSequence (1-letter): PLARTLSVAGLPGKK-OHStorage: -20 °C or belowSolubility: Soluble in water (1 mg/ml)

Syntide 2 is a synthetic peptide recognized as a substrate by Ca²⁺ calmodulin-dependent protein kinase II and Ca²⁺ phospholipid-dependent protein kinase (PKC). The sequence is homologous to phosphorylation site 2 on glycogen synthase. Syntide 2 has been used as a probe to assay localization of CaMKII activity and to study the effects of point mutations on phosphorylation activity.

References

1. Enslen, H. et al. (1994) “Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation” J. Biol. Chem. 269: 15520-15527.2. Yamazaki, T. et al. (1996) “Endothelin-1 Is Involved in Mechanical Stress-induced Cardiomyocyte Hypertrophy” J. Biol. Chem. 271: 3221-3228.