CAS Number: 138579-66-5Molecular Weight: 2198.1Salt Form: TFAPurity: >90%Sequence (3-letter): Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2Sequence (1-letter): GWTLNSAGYLLGPQQFFGLM-NH2Storage: -20 °C or below

Galantide is a chimeric peptide consisting of fragments of galanin and Substance P which acts as a reversible galanin receptor antagonist. The peptide antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets in a dose-dependant manner (IC50 = 1.0 nM). It antagonizes  the galanin-induced increase in K+ conductance IC50 = 4 nM).

References1) Lindskog S, et al. The novel high-affinity antagonist, galantide, blocks the galanin-mediated inhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992;210(2):183-188.2) Mulvaney JM, et al. Galantide distinguishes putative subtypes of galanin receptors in mudpuppy parasympathetic neurons. Eur J Pharmacol. 1995;287(1):97-100.