Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid formed by phosphorylation of sphingosine by sphingosine kinases. S1P binds to five G-protein coupled receptors designated S1P1-5 leading to cell proliferation, motility, and has a role in regulation cell shape. In addition, S1P acts as an intracellular mediator in a receptor-independent manner regulating cell survival and Ca2+ homeostasis. Sphingosine 1-phosphate fluorescein is a S1P analog with natural erythro stereochemistry labeled at the terminus of the alkyl chain with fluorescein.
Excitation/Emission: 494/521 nm
Bulk quantities of this product are available. Please email echelon@echelon-inc.com for more information.
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1) Peest, U., S. C. Sensken, et al. (2008). “S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake.” J Cell Biochem 104(3): 756-72.2) Meissner, A., J. Yang, et al. (2012). “Tumor Necrosis Factor-α-Mediated Downregulation of the Cystic Fibrosis Transmembrane Conductance Regulator Drives Pathological Sphingosine-1-Phosphate Signaling in a Mouse Model of Heart Failure.” Circulation 125(22): 2739-2750.3) Dickinson, A. J., et al. (2015). “Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood.” Integrative Biology 7(4): 392-401.4) Vogt, K., et al. (2018). “Release of Platelet-Derived Sphingosine-1-Phosphate Involves Multidrug Resistance Protein 4 (MRP4/ABCC4) and Is Inhibited by Statins.” Thromb Haemost 118(01): 132-142.
| Categories | Lipids |
|---|---|
| Filter | Fluorescent, Sphingolipid, Sphingosine 1-phosphate |
| Excitation/Emission | 491/521 mn |
| Molecular Formula | C39H52N3O11P |
| Molecular Weight (g/mol) | 769.8 |
| Purity | >95% |
| Storage | -20 °C or below, protect from light |
