Inositol phosphates are important signaling molecules involved in numerous cellular functions. Inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), aka IP3, is a second messenger produced by phospholipase C catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). IP3 binds to the IP3-receptor on the endoplasmic reticulum causing calcium to be released through the opening of a tetrameric ion channel. IP3 is rapidly metabolized by a specific series of inositol phosphatases and kinases.
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“Phosphatidylinositol and inositol phosphate metabolism.” J. Cell Sci. 2001, 114, 2207-8.
Keywords: D-myo-Inositol 1,4,5-trisphosphate, Ins(1,4,5)P3, I(1,4,5)P3, or IP3
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| Categories | Lipids |
|---|---|
| Filter | Inositol Phosphate |
| CAS Number | 108340-81-4 |
| Molecular Formula | C6H12Na3O15P3 |
| Molecular Weight (g/mol) | 486.04 |
| Purity | >95% |
| Storage | -20 °C or below |
