FPA-124 is a cell-permeable inhibitor of Akt (IC50 = 100 nM), binding to the PH and kinase domains. It inhibits cell proliferation in Colo357, BxPC3, BT20, and PC3 cancer cell lines with IC50 values ranging from 7-55 nM. FPA-124 inhibited tumor growth in mice with negligible toxicity.
References
Powered by Bioz See more details on Bioz1) V. Barve, et al. “Synthesis, Molecular Characterization, and Biological Activity of Novel SyntheticDerivatives of Chromen-4-one in Human Cancer Cells” J. Med. Chem., 2006, 49, 3800-3808.2) Biscetti, F., G. Straface, et al. (2009). “Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPARgamma stimulation.” Cardiovasc Diabetol 8: 49.3) Brito, P. M., R. l. Devillard, et al. (2009). “Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells.” Atherosclerosis 205(1): 126.
| Categories | Biochemical Reagents |
|---|---|
| Filter | Akt, Inhibitor |
| CAS Number | 902779-59-3 |
| Molecular Formula | C11H9Cl2CuN3O2S |
| Molecular Weight (g/mol) | 381.7 |
| Purity | 95% |
| Storage | 4 °C or below |
