梯队/3-a-氨基胆甾烷（3AC，SHIP1抑制剂）/10 MG/B-0341
商品编号：
B-0341
市场价：
¥6940.00
美元价：
3296.50
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. SHIP2 is ubiquitously expressed while SHIP1 is only found in hematopoietic lineage cells. 3AC is a selective inhibitor of SHIP1 (EC50 = 10 μM) and shows no inhibition of the other isoform, SHIP2, at concentrations up to 1 mM. 3AC promotes apoptosis of SHIP1-expressing leukemia cells (KG-1) and multiple myeloma cells (OPM) suggesting SHIP1 inhibition is a potential drug target for blood cancers. Mice treated with 3AC show increased numbers of MIR cells in the spleen and lymph nodes and increased numbers of granulocytes.
Powered by Bioz See more details on Bioz| Categories | Biochemical Reagents |
|---|---|
| Filter | Inhibitor, SHIP |
| CAS Number | 2206-20-4 |
| Molecular Formula | C27H49N |
| Molecular Weight (g/mol) | 387.68 |
| Purity | 95% |
| Storage | 4 °C or below |
品牌介绍
Echelon产品线★合成磷脂、磷酸肌醇、鞘脂及其衍生物★脂蛋白质相互作用工具★脂质含量检测试剂盒★脂质相关生物酶活性检测，抑制剂筛选试剂盒
